{"id":33,"date":"2023-08-28T21:42:28","date_gmt":"2023-08-28T21:42:28","guid":{"rendered":"https:\/\/onltherapeutics.com\/test\/?page_id=33"},"modified":"2026-04-01T14:15:22","modified_gmt":"2026-04-01T14:15:22","slug":"science","status":"publish","type":"page","link":"https:\/\/onltherapeutics.com\/test\/science\/","title":{"rendered":"Science"},"content":{"rendered":"\n<div class=\"wp-block-cover alignfull is-light has-parallax wp-duotone-rgb12355175-rgb13184246-1\" style=\"border-radius:40px;padding-left:var(--wp--preset--spacing--40);min-height:180px;aspect-ratio:unset;\"><div class=\"wp-block-cover__image-background wp-image-1796 has-parallax\" style=\"background-position:50% 50%;background-image:url(https:\/\/onltherapeutics.com\/test\/wp-content\/uploads\/2024\/01\/Banner_Cones_close.png)\"><\/div><span aria-hidden=\"true\" class=\"wp-block-cover__background has-background-dim-0 has-background-dim\"><\/span><div class=\"wp-block-cover__inner-container has-global-padding is-layout-constrained wp-container-core-cover-is-layout-a0f6d039 wp-block-cover-is-layout-constrained\">\n<p class=\"has-text-align-left has-base-color has-text-color has-link-color wp-elements-b7f9161707ab7559978c5cce0164f539\" style=\"padding-top:0;padding-right:0;padding-bottom:0;padding-left:0;font-size:clamp(2.2rem, 2.2rem + ((1vw - 0.2rem) * 4.235), 4rem);font-style:normal;font-weight:700;text-transform:none\">Science 1<\/p>\n<\/div><\/div>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns alignwide has-tertiary-background-color has-background is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\" style=\"border-radius:30px\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h3 class=\"wp-block-heading has-tertiary-background-color has-background\" style=\"padding-top:0;padding-right:0;padding-bottom:0;padding-left:0;font-size:clamp(22.041px, 1.378rem + ((1vw - 3.2px) * 2.053), 36px);text-transform:none\">ONL Therapeutics\u2019 primary scientific focus is Fas-mediated signaling, initiated by the activation of the Fas receptor at the cell surface and implicated in a variety of diseases<\/h3>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:70px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns alignwide are-vertically-aligned-center is-layout-flex wp-container-core-columns-is-layout-658170e2 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<h4 class=\"wp-block-heading\" style=\"padding-right:0;padding-left:0;font-size:clamp(15.747px, 0.984rem + ((1vw - 3.2px) * 1.214), 24px);font-style:normal;font-weight:600;text-transform:none\"><strong>How the Fas-Blocking Mechanism of Action Works<\/strong><\/h4>\n\n\n\n<p>Targeting Fas prevents activation of downstream death pathways and the inflammatory cascade that accelerates cell death and tissue damage. ONL&#8217;s lead therapeutic candidate, xelafaslatide (formerly ONL1204), is a small peptide Fas inhibitor designed to protect retinal cells and preserve vision in a range of blinding diseases.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"border-radius:0px;flex-basis:66.66%\">\n<figure class=\"wp-block-video\"><video controls poster=\"https:\/\/onltherapeutics.com\/test\/wp-content\/uploads\/2025\/07\/Video_still.png\" src=\"https:\/\/live-onl-therapeutics-website.pantheonsite.io\/\/wp-content\/uploads\/2025\/02\/ONL_FAS_MOA.mp4\"><\/video><\/figure>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:70px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns alignwide are-vertically-aligned-center is-layout-flex wp-container-core-columns-is-layout-658170e2 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"949\" height=\"613\" src=\"https:\/\/onltherapeutics.com\/test\/wp-content\/uploads\/2025\/10\/MOA_10_2025-1.svg\" alt=\"\" class=\"wp-image-2561\" style=\"aspect-ratio:1.5482794577685088;width:828px;height:auto\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<h4 class=\"wp-block-heading\" style=\"padding-right:0;padding-left:0;font-size:clamp(15.747px, 0.984rem + ((1vw - 3.2px) * 1.214), 24px);font-style:normal;font-weight:600;line-height:1.3;text-transform:none\"><strong>Disease Stress Leads&nbsp;to&nbsp;Fas Activation&nbsp;in&nbsp;Retinal Cells&nbsp;and&nbsp;Induces Fas Signaling, Which Triggers:<\/strong><\/h4>\n\n\n\n<p><\/p>\n\n\n\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-09686e84 wp-block-group-is-layout-constrained\" style=\"padding-top:0;padding-right:0;padding-bottom:0;padding-left:0\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:0px;flex-basis:14%\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"37\" height=\"37\" src=\"https:\/\/onltherapeutics.com\/test\/wp-content\/uploads\/2023\/09\/MOA_1.png\" alt=\"1.\" class=\"wp-image-472\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:82%\">\n<p>Cell death signaling cascades<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-09686e84 wp-block-group-is-layout-constrained\" style=\"padding-top:0;padding-right:0;padding-bottom:0;padding-left:0\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:12px;flex-basis:14%\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"37\" height=\"37\" src=\"https:\/\/onltherapeutics.com\/test\/wp-content\/uploads\/2023\/09\/MOA_2.png\" alt=\"2.\" class=\"wp-image-473\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:82%\">\n<p>Initiation of the production of chemokines and cytokines<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-417067bb wp-block-group-is-layout-constrained\" style=\"padding-top:0;padding-right:0;padding-bottom:0;padding-left:0\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:12px;flex-basis:14%\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"37\" height=\"37\" src=\"https:\/\/onltherapeutics.com\/test\/wp-content\/uploads\/2023\/09\/MOA_3.png\" alt=\"3.\" class=\"wp-image-474\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:82%\">\n<p>Chemokines and cytokines contribute to the inflammatory microenvironment and recruit additional immune cells that bring more Fas ligands to the retina<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:53px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-alpha-channel-opacity has-background is-style-wide\" style=\"background-color:#e6e6e6;color:#e6e6e6\"\/>\n\n\n\n<div style=\"height:35px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-20e9c67c wp-block-columns-is-layout-flex\" style=\"margin-top:0;margin-bottom:0;padding-right:0px;padding-left:0px\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p>Fas-mediated signaling is considered one of the body\u2019s cornerstone mechanisms for activating cell death. Death of vital cells is a root cause of a host of diseases and conditions and has been specifically associated with many ophthalmic diseases.<\/p>\n\n\n\n<p style=\"letter-spacing:0px\">In addition to its close association with cell death, Fas also plays a role in regulating immune signaling and associated inflammation. This distinct function of Fas is becoming more widely understood and appreciated. Fas-mediated immune signaling can induce additional cell death, increase damage to the surrounding tissues, and worsen the initial injury from the disease.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p>Fas-mediated cell death and immune signaling have been implicated in the development and progression of many diseases and conditions. ONL and others have demonstrated vital roles for Fas in a wide range of retinal disease, including retinal detachment, dry and wet age-related macular degeneration, uveitis, diabetic retinopathy, glaucoma, and optic neuropathies.<\/p>\n\n\n\n<p>Inhibition of Fas signaling at the receptor represents the most direct and upstream approach to preventing its negative impact. ONL believes that the therapeutic benefits of blocking Fas activation and its subsequent signaling may have wide-ranging clinical value for patients suffering from retinal diseases.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>ONL Therapeutics\u2019 primary scientific focus is Fas-mediated signaling, initiated by the activation of the Fas receptor at the cell surface and implicated in a variety of diseases How the Fas-Blocking Mechanism of Action Works Targeting Fas prevents activation of downstream death pathways and the inflammatory cascade that accelerates cell death and tissue damage. ONL&#8217;s lead [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"blank","meta":{"ngg_post_thumbnail":0,"footnotes":""},"class_list":["post-33","page","type-page","status-publish","hentry"],"featured_image_urls_v2":{"full":"","thumbnail":"","medium":"","medium_large":"","large":"","1536x1536":"","2048x2048":"","gform-image-choice-sm":"","gform-image-choice-md":"","gform-image-choice-lg":""},"post_excerpt_stackable_v2":"<p>Science 1 ONL Therapeutics\u2019 primary scientific focus is Fas-mediated signaling, initiated by the activation of the Fas receptor at the cell surface and implicated in a variety of diseases How the Fas-Blocking Mechanism of Action Works Targeting Fas prevents activation of downstream death pathways and the inflammatory cascade that accelerates cell death and tissue damage. ONL&#8217;s lead therapeutic candidate, xelafaslatide (formerly ONL1204), is a small peptide Fas inhibitor designed to protect retinal cells and preserve vision in a range of blinding diseases. Disease Stress Leads&nbsp;to&nbsp;Fas Activation&nbsp;in&nbsp;Retinal Cells&nbsp;and&nbsp;Induces Fas Signaling, Which Triggers: Cell death signaling cascades Initiation of the production of&hellip;<\/p>\n","category_list_v2":"","author_info_v2":{"name":"theo@myriadweb.com","url":"https:\/\/onltherapeutics.com\/test\/author\/theomyriadweb-com\/"},"comments_num_v2":"0 comments","_links":{"self":[{"href":"https:\/\/onltherapeutics.com\/test\/wp-json\/wp\/v2\/pages\/33","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/onltherapeutics.com\/test\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/onltherapeutics.com\/test\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/onltherapeutics.com\/test\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/onltherapeutics.com\/test\/wp-json\/wp\/v2\/comments?post=33"}],"version-history":[{"count":57,"href":"https:\/\/onltherapeutics.com\/test\/wp-json\/wp\/v2\/pages\/33\/revisions"}],"predecessor-version":[{"id":2813,"href":"https:\/\/onltherapeutics.com\/test\/wp-json\/wp\/v2\/pages\/33\/revisions\/2813"}],"wp:attachment":[{"href":"https:\/\/onltherapeutics.com\/test\/wp-json\/wp\/v2\/media?parent=33"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}